SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

Platelet dense granules are members of a family of tissue-specific, lysosome-related organelles that also includes melanosomes in melanocytes. Contents released from dense granules after platelet activation promote coagulation and hemostasis, and dense granule defects such as those seen in Hermansky...

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Main Authors: Meng, Ronghua, Wang, Yuhuan, Yao, Yu, Zhang, Zhe, Harper, Dawn C., Heijnen, Harry F. G., Sitaram, Anand, Li, Wei, Raposo, Graça, Weiss, Mitchell J., Poncz, Mortimer, Marks, Michael S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2012
Ábhair:
Platelets and Thrombopoiesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398753/
https://ncbi.nlm.nih.gov/pubmed/22611153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-389551
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