Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, bleeding diathesis, and other variable symptoms. The bleeding diathesis has been attributed to δ storage pool deficiency, reflecting the malformation of platelet dense granules. Here, we analyzed agonist-stimulated secretio...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Meng, Ronghua, Wu, Jie, Harper, Dawn C., Wang, Yuhuan, Kowalska, M. Anna, Abrams, Charles S., Brass, Lawrence F., Poncz, Mortimer, Stalker, Timothy J., Marks, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351507/
https://ncbi.nlm.nih.gov/pubmed/25477496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-586727
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