Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, bleeding diathesis, and other variable symptoms. The bleeding diathesis has been attributed to δ storage pool deficiency, reflecting the malformation of platelet dense granules. Here, we analyzed agonist-stimulated secretio...

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Vydáno v:Blood
Hlavní autoři: Meng, Ronghua, Wu, Jie, Harper, Dawn C., Wang, Yuhuan, Kowalska, M. Anna, Abrams, Charles S., Brass, Lawrence F., Poncz, Mortimer, Stalker, Timothy J., Marks, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2015
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351507/
https://ncbi.nlm.nih.gov/pubmed/25477496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-586727
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