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SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α
Hypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positiv...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4637857/ https://ncbi.nlm.nih.gov/pubmed/26548925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16396 |
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