Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.

We have used two-dimensional 1H NMR spectroscopy to study the conformation of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG) in solution. This is one of a series of thrombin-binding DNA aptamers with a consensus 15-base sequence that was recently isolated and shown to inhibit thrombin-catalyzed fib...

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Bibliographische Detailangaben
Hauptverfasser: Macaya, R F, Schultze, P, Smith, F W, Roe, J A, Feigon, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC46378/
https://ncbi.nlm.nih.gov/pubmed/8475124
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