Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution.
We have used two-dimensional 1H NMR spectroscopy to study the conformation of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG) in solution. This is one of a series of thrombin-binding DNA aptamers with a consensus 15-base sequence that was recently isolated and shown to inhibit thrombin-catalyzed fib...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475124/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3745 |
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