Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes w...

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Bibliografski detalji
Izdano u:Aging (Albany NY)
Glavni autori: Yue, Fei, Li, Wenjiao, Zou, Jing, Chen, Qi, Xu, Guibin, Huang, Hai, Xu, Zhen, Zhang, Sheng, Gallinari, Paola, Wang, Fen, McKeehan, Wallace L., Liu, Leyuan
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637209/
https://ncbi.nlm.nih.gov/pubmed/26540094
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