Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

Autophagy controls and executes the turnover of abnormally aggregated proteins. MAP1S interacts with the autophagy marker LC3 and positively regulates autophagy flux. HDAC4 associates with the aggregation-prone mutant huntingtin protein (mHTT) that causes Huntington's disease, and colocalizes w...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Yue, Fei, Li, Wenjiao, Zou, Jing, Chen, Qi, Xu, Guibin, Huang, Hai, Xu, Zhen, Zhang, Sheng, Gallinari, Paola, Wang, Fen, McKeehan, Wallace L., Liu, Leyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4637209/
https://ncbi.nlm.nih.gov/pubmed/26540094
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados