Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults

VRC-HIVMAB060-00-AB (VRC01) is a broadly neutralizing HIV-1 monoclonal antibody (mAb) isolated from the B cells of an HIV-infected patient. It is directed against the HIV-1 CD4 binding site and is capable of potently neutralizing the majority of diverse HIV-1 strains. This Phase I dose-escalation st...

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Publicat a:Clin Exp Immunol
Autors principals: Ledgerwood, J E, Coates, E E, Yamshchikov, G, Saunders, J G, Holman, L, Enama, M E, DeZure, A, Lynch, R M, Gordon, I, Plummer, S, Hendel, C S, Pegu, A, Conan-Cibotti, M, Sitar, S, Bailer, R T, Narpala, S, McDermott, A, Louder, M, O'Dell, S, Mohan, S, Pandey, J P, Schwartz, R M, Hu, Z, Koup, R A, Capparelli, E, Mascola, J R, Graham, B S
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636891/
https://ncbi.nlm.nih.gov/pubmed/26332605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12692
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