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53BP1 and the LINC complex promote microtubule-dependent DSB mobility and DNA repair

Increased mobility of chromatin surrounding Double Strand Breaks (DSBs) has been noted in yeast and mammalian cells but how it is driven and whether it contributes to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We fin...

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Publicat a:Cell
Autors principals: Lottersberger, Francisca, Karssemeijer, Roos Anna, Dimitrova, Nadya, de Lange, Titia
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636737/
https://ncbi.nlm.nih.gov/pubmed/26544937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.09.057
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