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Delivering on the promise: PARP inhibition as targeted anti-cancer therapy

PURPOSE OF THE REVIEW: Authors present the rationale, clinical development, and current status of Poly (adenosine diphospohate [ADP]) ribose polymerase (PARP) inhibitors (PARPi) as anticancer agents. RECENT FINDINGS: The recent approval of olaparib in heavily pre-treated patients with advanced ovari...

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Publicat a:Curr Opin Oncol
Autors principals: Coyne, Geraldine O'Sullivan, Chen, Alice, Kummar, Shivaani
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636335/
https://ncbi.nlm.nih.gov/pubmed/26447876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCO.0000000000000238
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