Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier

The impermeability of the adult blood-brain barrier (BBB) to lysosomal enzymes impedes the ability to treat the central nervous system manifestations of lysosomal storage diseases. Here, we found that simultaneous stimulation of the alpha1 and alpha2 adrenoreceptor restores in adult mice the high ra...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Urayama, Akihiko, Dohgu, Shinya, Robinson, Sandra M., Sly, William S., Grubb, Jeffery H., Banks, William A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2015
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636227/
https://ncbi.nlm.nih.gov/pubmed/26545208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142347
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