Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts

AIM: To evaluate the structure–activity relationship of oxime ether lipids (OELs) containing modifications in the hydrophobic domains (chain length, degree of unsaturation) and hydrophilic head groups (polar domain hydroxyl groups) toward complex formation with siRNA molecules and siRNA delivery eff...

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Detalhes bibliográficos
Publicado no:Nanomedicine (Lond)
Main Authors: Gupta, Kshitij, Mattingly, Stephanie J, Knipp, Ralph J, Afonin, Kirill A, Viard, Mathias, Bergman, Joseph T, Stepler, Marissa, Nantz, Michael H, Puri, Anu, Shapiro, Bruce A
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636123/
https://ncbi.nlm.nih.gov/pubmed/26107486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.105
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