Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts

AIM: To evaluate the structure–activity relationship of oxime ether lipids (OELs) containing modifications in the hydrophobic domains (chain length, degree of unsaturation) and hydrophilic head groups (polar domain hydroxyl groups) toward complex formation with siRNA molecules and siRNA delivery eff...

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Dettagli Bibliografici
Pubblicato in:Nanomedicine (Lond)
Autori principali: Gupta, Kshitij, Mattingly, Stephanie J, Knipp, Ralph J, Afonin, Kirill A, Viard, Mathias, Bergman, Joseph T, Stepler, Marissa, Nantz, Michael H, Puri, Anu, Shapiro, Bruce A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Future Medicine Ltd 2015
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636123/
https://ncbi.nlm.nih.gov/pubmed/26107486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.105
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