Oxime ether lipids containing hydroxylated head groups are more superior siRNA delivery agents than their nonhydroxylated counterparts

AIM: To evaluate the structure–activity relationship of oxime ether lipids (OELs) containing modifications in the hydrophobic domains (chain length, degree of unsaturation) and hydrophilic head groups (polar domain hydroxyl groups) toward complex formation with siRNA molecules and siRNA delivery eff...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nanomedicine (Lond)
Prif Awduron: Gupta, Kshitij, Mattingly, Stephanie J, Knipp, Ralph J, Afonin, Kirill A, Viard, Mathias, Bergman, Joseph T, Stepler, Marissa, Nantz, Michael H, Puri, Anu, Shapiro, Bruce A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Future Medicine Ltd 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636123/
https://ncbi.nlm.nih.gov/pubmed/26107486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.15.105
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