Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). However, the delivery of naked siRNAs is challenging becaus...

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Vydáno v:Mol Ther Nucleic Acids
Hlavní autoři: Kim, Taejin, Viard, Mathias, Afonin, Kirill A., Gupta, Kshitij, Popov, Mary, Salotti, Jacqueline, Johnson, Peter F., Linder, Charles, Heldman, Eliahu, Shapiro, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7090283/
https://ncbi.nlm.nih.gov/pubmed/32200271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.02.011
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