In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles...

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Autors principals: Kim, Taejin, Afonin, Kirill A., Viard, Mathias, Koyfman, Alexey Y, Sparks, Selene, Heldman, Eliahu, Grinberg, Sarina, Linder, Charles, Blumenthal, Robert P, Shapiro, Bruce A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615820/
https://ncbi.nlm.nih.gov/pubmed/23511334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.5
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