In Silico, In Vitro, and In Vivo Studies Indicate the Potential Use of Bolaamphiphiles for Therapeutic siRNAs Delivery

Specific small interfering RNAs (siRNAs) designed to silence different oncogenic pathways can be used for cancer therapy. However, non-modified naked siRNAs have short half-lives in blood serum and encounter difficulties in crossing biological membranes due to their negative charge. These obstacles...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Taejin, Afonin, Kirill A., Viard, Mathias, Koyfman, Alexey Y, Sparks, Selene, Heldman, Eliahu, Grinberg, Sarina, Linder, Charles, Blumenthal, Robert P, Shapiro, Bruce A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615820/
https://ncbi.nlm.nih.gov/pubmed/23511334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.5
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