Triggering co-stimulation directly in melanoma tumor fragments drives CD8(+) tumor-infiltrating lymphocyte expansion with improved effector-memory properties

TIL from solid tumors can express activation/co-stimulatory molecules like 4–1BB/CD137, a sign of recent antigenic stimulation in the tumor microenvironment (TME). This activated state can be exploited ex vivo to enhance the expansion of tumor-reactive CD8(+) TIL for adoptive cell therapy through di...

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Publicado en:Oncoimmunology
Main Authors: Chacon, Jessica Ann, Sarnaik, Amod A, Pilon-Thomas, Shari, Radvanyi, Laszlo
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635692/
https://ncbi.nlm.nih.gov/pubmed/26587314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1040219
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