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Triggering co-stimulation directly in melanoma tumor fragments drives CD8(+) tumor-infiltrating lymphocyte expansion with improved effector-memory properties
TIL from solid tumors can express activation/co-stimulatory molecules like 4–1BB/CD137, a sign of recent antigenic stimulation in the tumor microenvironment (TME). This activated state can be exploited ex vivo to enhance the expansion of tumor-reactive CD8(+) TIL for adoptive cell therapy through di...
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| Опубликовано в: : | Oncoimmunology |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4635692/ https://ncbi.nlm.nih.gov/pubmed/26587314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1040219 |
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