Manipulating the tumor microenvironment ex vivo for enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy

PURPOSE: Cultured tumor fragments from melanoma metastases have been used for years as a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy. The expansion of tumor-reactive CD8(+) T cells with IL-2 in these early cultures is critical in generating clinically active TIL infusion...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Chacon, Jessica Ann, Sarnaik, Amod A, Chen, Jie Qing, Creasy, Caitlin, Kale, Charuta, Robinson, John, Weber, Jeffrey, Hwu, Patrick, Pilon-Thomas, Shari, Radvanyi, Laszlo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315752/
https://ncbi.nlm.nih.gov/pubmed/25472998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1934
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