Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8(+) Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor regression in up to 50% or more of patients with unresectable metastatic melanoma. However, current methods to expand melanoma TIL, especially the “rapid expansion protocol” (REP) were not designed to enhance t...

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Bibliographische Detailangaben
Hauptverfasser: Chacon, Jessica Ann, Wu, Richard C., Sukhumalchandra, Pariya, Molldrem, Jeffrey J., Sarnaik, Amod, Pilon-Thomas, Shari, Weber, Jeffrey, Hwu, Patrick, Radvanyi, Laszlo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613355/
https://ncbi.nlm.nih.gov/pubmed/23560068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060031
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