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Chronic Exposure to Particulate Chromate Induces Premature Centrosome Separation and Centriole Disengagement in Human Lung Cells

Particulate hexavalent chromium (Cr(VI)) is a well-established human lung carcinogen. Lung tumors are characterized by structural and numerical chromosome instability. Centrosome amplification is a phenotype commonly found in solid tumors, including lung tumors, which strongly correlates with chromo...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Martino, Julieta, Holmes, Amie L., Xie, Hong, Wise, Sandra S., Wise, John Pierce
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635651/
https://ncbi.nlm.nih.gov/pubmed/26293554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv146
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