Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis

AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models. METHODS: The cyclic guanosine monophosphate (cGMP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cel...

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Vydáno v:World J Gastrointest Pharmacol Ther
Hlavní autoři: Shailubhai, Kunwar, Palejwala, Vaseem, Arjunan, Krishna Priya, Saykhedkar, Sayali, Nefsky, Bradley, Foss, John A, Comiskey, Stephen, Jacob, Gary S, Plevy, Scott E
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2015
Témata:
Basic Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635161/
https://ncbi.nlm.nih.gov/pubmed/26558155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4292/wjgpt.v6.i4.213
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