microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain

Dysregulation of amyloid-β (Aβ) metabolism is critical for Alzheimer's disease (AD) pathogenesis. Mounting evidence suggests that apolipoprotein E (ApoE) is involved in Aβ metabolism. ATP-binding cassette transporter A1 (ABCA1) is a key regulator of ApoE lipidation, which affects Aβ levels. The...

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Publicado no:J Neurosci
Main Authors: Kim, Jaekwang, Yoon, Hyejin, Horie, Takahiro, Burchett, Jack M., Restivo, Jessica L., Rotllan, Noemi, Ramírez, Cristina M., Verghese, Philip B., Ihara, Masafumi, Hoe, Hyang-Sook, Esau, Christine, Fernández-Hernando, Carlos, Holtzman, David M., Cirrito, John R., Ono, Koh, Kim, Jungsu
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635126/
https://ncbi.nlm.nih.gov/pubmed/26538644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2053-15.2015
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