Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status. However it is unknown whether regulation of SAM and SAH by nutrient availability can be directly sensed to alter the kinetics of key histone methylation marks. We provide evidence that the s...

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Bibliografiska uppgifter
I publikationen:Cell Metab
Huvudupphovsmän: Mentch, Samantha J, Merhmohamadi, Mahya, Huang, Lei, Liu, Xiaojing, Gupta, Diwaker, Mattocks, Dwight, Gomez, Paola, Ables, Gene, Bamman, Marcas M., Thalacker-Mercer, Anna E, Nichenametla, Sailendra, Locasale, Jason W
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635069/
https://ncbi.nlm.nih.gov/pubmed/26411344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.08.024
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