Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR die...

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Pubblicato in:Exp Gerontol
Autori principali: Mattocks, Dwight AL, Mentch, Samantha J, Shneyder, Jelena, Ables, Gene P, Sun, Dongxiao, Richie, John P, Locasale, Jason W, Nichenametla, Sailendra N
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906125/
https://ncbi.nlm.nih.gov/pubmed/27940170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2016.12.003
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