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Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice
Despite well-documented evidence for lifespan extension by methionine restriction (MR), underlying mechanisms remain unknown. As methionine can alter S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the substrate and product of DNA methyltransferase-1 (DNMT1), we hypothesized that MR die...
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| Vydáno v: | Exp Gerontol |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5906125/ https://ncbi.nlm.nih.gov/pubmed/27940170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2016.12.003 |
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