Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status. However it is unknown whether regulation of SAM and SAH by nutrient availability can be directly sensed to alter the kinetics of key histone methylation marks. We provide evidence that the s...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Mentch, Samantha J, Merhmohamadi, Mahya, Huang, Lei, Liu, Xiaojing, Gupta, Diwaker, Mattocks, Dwight, Gomez, Paola, Ables, Gene, Bamman, Marcas M., Thalacker-Mercer, Anna E, Nichenametla, Sailendra, Locasale, Jason W
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635069/
https://ncbi.nlm.nih.gov/pubmed/26411344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.08.024
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