Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells

Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide ((·)NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and death. We have previously shown that (·)NO...

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Veröffentlicht in:PLoS One
Hauptverfasser: Sharma, Nilesh K., Kumar, Ashutosh, Kumari, Amrita, Tokar, Erik J., Waalkes, Michael P., Bortner, Carl D., Williams, Jason, Ehrenshaft, Marilyn, Mason, Ronald P., Sinha, Birandra K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635000/
https://ncbi.nlm.nih.gov/pubmed/26540186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141897
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