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Synergistic Enhancement of Topotecan-Induced Cell Death by Ascorbic Acid in Human Breast MCF-7 Tumor Cells

Topotecan, a derivative of camptothecin, is an important anticancer drug for the treatment of various human cancers in the clinic. While the principal mechanism of tumor cell killing by topotecan is due to its interactions with topoisomerase I, other mechanisms, e.g., oxidative stress induced by rea...

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Détails bibliographiques
Publié dans:Free Radic Biol Med
Auteurs principaux: Sinha, Birandra K., van ‘t Erve, Thomas J., Kumar, Ashutosh, Bortner, Carl D., Motten, Ann G., Mason, Ronald P.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699936/
https://ncbi.nlm.nih.gov/pubmed/29079526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.10.377
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