Synergistic Enhancement of Topotecan-Induced Cell Death by Ascorbic Acid in Human Breast MCF-7 Tumor Cells

Topotecan, a derivative of camptothecin, is an important anticancer drug for the treatment of various human cancers in the clinic. While the principal mechanism of tumor cell killing by topotecan is due to its interactions with topoisomerase I, other mechanisms, e.g., oxidative stress induced by rea...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Sinha, Birandra K., van ‘t Erve, Thomas J., Kumar, Ashutosh, Bortner, Carl D., Motten, Ann G., Mason, Ronald P.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699936/
https://ncbi.nlm.nih.gov/pubmed/29079526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.10.377
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