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Nitric Oxide Inhibits Topoisomerase II Activity and Induces Resistance to Topoisomerase II-Poisons in Human Tumor Cells
BACKGROUND: Etoposide and doxorubicin, topoisomerase II poisons, are important drugs for the treatment of tumors in the clinic. Topoisomerases contain several free sulfhydryl groups which are important for their activity and are also potential targets for nitric oxide ((•)NO)-induced nitrosation. (•...
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| Publié dans: | Biochim Biophys Acta |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909546/ https://ncbi.nlm.nih.gov/pubmed/27095671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.04.009 |
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