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Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability
The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. We introduce a coupled Bayesian regression approach—eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies c...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Pub. Group
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4633824/ https://ncbi.nlm.nih.gov/pubmed/26456756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9555 |
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