Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability

The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. We introduce a coupled Bayesian regression approach—eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies c...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Das, Avinash, Morley, Michael, Moravec, Christine S., Tang, W. H. W., Hakonarson, Hakon, Margulies, Kenneth B., Cappola, Thomas P., Jensen, Shane, Hannenhalli, Sridhar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633824/
https://ncbi.nlm.nih.gov/pubmed/26456756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9555
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