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Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer

With the recent comprehensive mapping of cancer genomes, there is now a need for functional approaches to edit the aberrant epigenetic state of key cancer drivers to reprogram the epi-pathology of the disease. In this study we utilized a programmable DNA-binding methyltransferase to induce targeted...

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Bibliografski detalji
Izdano u:Oncogene
Glavni autori: Stolzenburg, S, Beltran, A S, Swift-Scanlan, T, Rivenbark, A G, Rashwan, R, Blancafort, P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633433/
https://ncbi.nlm.nih.gov/pubmed/25684141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.470
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