Altered Protein S-Glutathionylation Identifies a Potential Mechanism of Resistance to Acetaminophen-Induced Hepatotoxicity

Acetaminophen (APAP) is the most commonly used over-the-counter analgesic. However, hepatotoxicity induced by APAP is a major clinical issue, and the factors that define sensitivity to APAP remain unclear. We have previously demonstrated that mice nulled for glutathione S-transferase Pi (GSTP) are r...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: McGarry, David J., Chakravarty, Probir, Wolf, C. Roland, Henderson, Colin J.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631951/
https://ncbi.nlm.nih.gov/pubmed/26311813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.227389
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