Reactive Metabolite-induced Protein Glutathionylation: A Potentially Novel Mechanism Underlying Acetaminophen Hepatotoxicity

Although covalent protein binding is established as the pivotal event underpinning acetaminophen (APAP) toxicity, its mechanistic details remain unclear. In this study, we demonstrated that APAP induces widespread protein glutathionylation in a time-, dose- and bioactivation-dependent manner in Hepa...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Chan, James Chun Yip, Soh, Alex Cheow Khoon, Kioh, Dorinda Yan Qin, Li, Jianguo, Verma, Chandra, Koh, Siew Kwan, Beuerman, Roger Wilmer, Zhou, Lei, Chan, Eric Chun Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2018
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166671/
https://ncbi.nlm.nih.gov/pubmed/30006487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA118.000875
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