Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity

BACKGROUND: Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses t...

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Detalhes bibliográficos
Main Authors: Amaral, Sylvia S, Oliveira, André G, Marques, Pedro E, Quintão, Jayane L D, Pires, Daniele A, Resende, Rodrigo R, Sousa, Bruna R, Melgaço, Juliana G, Pinto, Marcelo A, Russo, Remo C, Gomes, Ariane K C, Andrade, Lidia M, Zanin, Rafael F, Pereira, Rafaela V S, Bonorino, Cristina, Soriani, Frederico M, Lima, Cristiano X, Cara, Denise C, Teixeira, Mauro M, Leite, Maria F, Menezes, Gustavo B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608937/
https://ncbi.nlm.nih.gov/pubmed/23384127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-10
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