Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity

BACKGROUND: Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses t...

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Autori principali: Amaral, Sylvia S, Oliveira, André G, Marques, Pedro E, Quintão, Jayane L D, Pires, Daniele A, Resende, Rodrigo R, Sousa, Bruna R, Melgaço, Juliana G, Pinto, Marcelo A, Russo, Remo C, Gomes, Ariane K C, Andrade, Lidia M, Zanin, Rafael F, Pereira, Rafaela V S, Bonorino, Cristina, Soriani, Frederico M, Lima, Cristiano X, Cara, Denise C, Teixeira, Mauro M, Leite, Maria F, Menezes, Gustavo B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608937/
https://ncbi.nlm.nih.gov/pubmed/23384127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-10
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