Changes in Mouse Liver Protein Glutathionylation after Acetaminophen Exposure

The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300 mg/kg APAP in B6C3F1 mice produced increased serum alanine aminotransferase and aspartate aminotransferase levels and liver necrosis in a dose-de...

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Detalhes bibliográficos
Main Authors: Yang, Xi, Greenhaw, James, Ali, Akhtar, Shi, Qiang, Roberts, Dean W., Hinson, Jack A., Muskhelishvili, Levan, Beger, Richard, Pence, Lisa M., Ando, Yosuke, Sun, Jinchun, Davis, Kelly, Salminen, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263967/
https://ncbi.nlm.nih.gov/pubmed/22045778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.187948
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