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Molecular Pathways: Targeting ATR in Cancer Therapy
The human ATR gene encodes a kinase that is activated by DNA damage and replication stress as a central transducer of a checkpoint signaling pathway. Once activated, ATR phosphorylates multiple substrates, including the kinase Chk1, to regulate cell cycle progression, replication fork stability, and...
Enregistré dans:
| Publié dans: | Clin Cancer Res |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4631635/ https://ncbi.nlm.nih.gov/pubmed/26362996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0479 |
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