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Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy
The p53 tumor suppressor is activated in response to cellular stresses to induce cell cycle arrest, cellular senescence, and apoptosis. The p53 gene is inactivated by mutations in more than 50% of human tumors. In addition, tumor cells dampen p53 activities via overexpression of p53 negative regulat...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3537867/ https://ncbi.nlm.nih.gov/pubmed/23262034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0053 |
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