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Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

The p53 tumor suppressor is activated in response to cellular stresses to induce cell cycle arrest, cellular senescence, and apoptosis. The p53 gene is inactivated by mutations in more than 50% of human tumors. In addition, tumor cells dampen p53 activities via overexpression of p53 negative regulat...

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Detalhes bibliográficos
Main Authors: Li, Qin, Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537867/
https://ncbi.nlm.nih.gov/pubmed/23262034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0053
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