GGGGCC repeat expansion in C9ORF72 compromises nucleocytoplasmic transport

GGGGCC (G(4)C(2)) repeat expansion in a noncoding region of C9ORF72 is the most common cause of sporadic and familial forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)(1,2). The basis for pathogenesis is unknown. To capture the consequences of G(4)C(2) repeat expansion i...

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Опубликовано в: :Nature
Главные авторы: Freibaum, Brian D., Lu, Yubing, Lopez-Gonzalez, Rodrigo, Kim, Nam Chul, Almeida, Sandra, Lee, Kyung-Ha, Badders, Nisha, Valentine, Marc, Miller, Bruce L., Wong, Philip C., Petrucelli, Leonard, Kim, Hong Joo, Gao, Fen-Biao, Taylor, J. Paul
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631399/
https://ncbi.nlm.nih.gov/pubmed/26308899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14974
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