Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

HuR, an RNA binding protein, binds to adenine- and uridine-rich elements (ARE) in the 3′-untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is highly abundant in many types of cancer, and it promotes tumorigenesis by interacting with cancer-associated mRNAs, w...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Wu, Xiaoqing, Lan, Lan, Wilson, David Michael, Marquez, Rebecca T., Tsao, Wei-chung, Gao, Philip, Roy, Anuradha, Turner, Benjamin Andrew, McDonald, Peter, Tunge, Jon A, Rogers, Steven A, Dixon, Dan A., Aubé, Jeffrey, Xu, Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631057/
https://ncbi.nlm.nih.gov/pubmed/25750985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500851u
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