Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes

Studies in myeloid neoplasms have described recurrent IDH1 and IDH2 mutations as primarily mutually exclusive. Over a 6-month period of clinical testing with a targeted next-generation sequencing assay, we evaluated 92 patients with acute myeloid leukemia, myelodysplastic syndrome, and chronic myelo...

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Pubblicato in:J Mol Diagn
Autori principali: Platt, Mia Y., Fathi, Amir T., Borger, Darrell R., Brunner, Andrew M., Hasserjian, Robert P., Balaj, Leonora, Lum, Amy, Yip, Stephen, Dias-Santagata, Dora, Zheng, Zongli, Le, Long P., Graubert, Timothy A., Iafrate, A. John, Nardi, Valentina
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2015
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630164/
https://ncbi.nlm.nih.gov/pubmed/26331834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2015.06.004
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