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Total Synthesis and Absolute Stereochemistry of the Proteasome Inhibitors Cystargolides A and B
The absolute stereochemistry of the cystargolides was determined by total synthesis. Evaluation of synthetic cystargolides and derivatives showed that the natural (2S,3R) stereochemistry is essential for activity. Moreover, benzyl esters (−)-10 and (−)-15 were found to be about 100 times more potent...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629797/ https://ncbi.nlm.nih.gov/pubmed/26400369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01821h |
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