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Site-specific PEGylation of lidamycin and its antitumor activity
In this study, N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein (rLDP) of lidamycin (LDM) was prepared using a polyethyleneglycol (PEG) derivative (M(w) 20 kDa) through a reactive terminal aldehyde group under weak acidic conditions (pH 5.5). The biochemical propertie...
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| Publicado no: | Acta Pharm Sin B |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629235/ https://ncbi.nlm.nih.gov/pubmed/26579455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2015.03.006 |
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