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Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity
Mammalian ribonucleases are emerging as cancer chemotherapeutic agents. Their cationicity engenders cell permeability, and their enzymatic activity destroys the biochemical information encoded by RNA. The pharmacologic potential of ribonucleases is, however, obviated by their high sensitivity to a c...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3166498/ https://ncbi.nlm.nih.gov/pubmed/21633186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.3.15959 |
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