Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload

Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-deriv...

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Pubblicato in:Sci Rep
Autori principali: Yano, Masamichi, Akazawa, Hiroshi, Oka, Toru, Yabumoto, Chizuru, Kudo-Sakamoto, Yoko, Kamo, Takehiro, Shimizu, Yu, Yagi, Hiroki, Naito, Atsuhiko T., Lee, Jong-Kook, Suzuki, Jun-ichi, Sakata, Yasushi, Komuro, Issei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629142/
https://ncbi.nlm.nih.gov/pubmed/26522369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15857
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