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Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-deriv...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2015
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629142/ https://ncbi.nlm.nih.gov/pubmed/26522369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15857 |
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