Trastuzumab resistance induces EMT to transform HER2(+) PTEN(−) to a triple negative breast cancer that requires unique treatment options

Although trastuzumab is an effective treatment in early stage HER2(+) breast cancer the majority of advanced HER2(+) breast cancers develop trastuzumab resistance, especially in the 40% of breast cancers with loss of PTEN. However, HER2(+) breast cancer patients continue to receive trastuzumab regar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Burnett, Joseph P., Korkaya, Hasan, Ouzounova, Maria D., Jiang, Hui, Conley, Sarah J., Newman, Bryan W., Sun, Lichao, Connarn, Jamie N., Chen, Ching-Shih, Zhang, Ning, Wicha, Max S., Sun, Duxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629137/
https://ncbi.nlm.nih.gov/pubmed/26522776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15821
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