Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer

Continued use of trastuzumab in PTEN-deficient HER2+ breast cancer induces the epithelial-to-mesenchymal transition (EMT), transforms HER2+ to triple negative breast cancer, and expands breast cancer stem cells (BCSCs). Using cancer cell lines with two distinct states, epithelial and mesenchymal, we...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Sun, Lichao, Burnett, Joseph, Gasparyan, Mari, Xu, Fangying, Jiang, Hui, Lin, Chang-Ching, Myers, Ila, Korkaya, Hasan, Liu, Yajing, Connarn, Jamie, He, Huining, Zhang, Ning, Wicha, Max S., Sun, Duxin
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239484/
https://ncbi.nlm.nih.gov/pubmed/27285982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9839
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