PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

Poor trastuzumab (Tmab) response of patients with human epidermal growth factor receptor 2-overexpressing gastric or gastroesophageal junction adenocarcinoma (HER2-GEA) is associated with the inhibition of phosphatase and tensin homolog (PTEN) expression. In this multicenter, retrospective observati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yokoyama, Daiju, Hisamori, Shigeo, Deguchi, Yasunori, Nishigori, Tatsuto, Okabe, Hiroshi, Kanaya, Seiichiro, Manaka, Dai, Kadokawa, Yoshio, Hata, Hiroaki, Minamiguchi, Sachiko, Tsunoda, Shigeru, Obama, Kazutaka, Sakai, Yoshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079403/
https://ncbi.nlm.nih.gov/pubmed/33907203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88331-3
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